Fabrication and properties of carboxymethyl chitosan/polyethylene oxide composite nonwoven mats by centrifugal spinning

Carboxymethyl chitosan/polyethylene oxide (CMCS/PEO) mixed composition nonwoven mats with the average mat basis weight of 34.53–49.63 g/m2 were prepared by centrifugal spinning from homogeneous aqueous solution for potential use as wound dressings. The weight fraction composition of CMCS/PEO investigated was 40/60 to 60/40. The CMCS/PEO fibers were found to have normally distributed, monomodal, average diameters ranging from 1.91 ?m (55 % CMCS) to 3.22 ?m (50 % CMCS). Addition of CMCS to PEO (40 % CMCS) resulted in appearance of a wide angle x-ray diffraction (WXRD) peak at 18.9°. The CMCS and PEO fibers were demonstrated by differential scanning calorimetry and WXRD to be mixtures of the two paracrystalline polymers. The composite nonwoven mats with 60 % weight of CMCS demonstrated Log2 reduction at 24 h against Staphylococcus aureus inoculation (104 cfg/mL).

» Author: Chen Li, Yu Huang, Renhao Li, Yun Wang, Xin Xiang, Chunhua Zhang, Dong Wang, Yingshan Zhou, Xin Liu, Weilin Xu

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This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement Nº 737882.


            

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